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Fungal Metabologenomics
Fungal Metabologenomics
We probed fungi for anticancer, antifungal, and antiparasitic activity through high throughput bioactivity screening, metabolomics based bioactive molecule identification and genomics analysis to identify the biosynthetic gene clusters that are making those bioactive molecules using a metabologenomics platform.
We probed fungi for anticancer, antifungal, and antiparasitic activity through high throughput bioactivity screening, metabolomics based bioactive molecule identification and genomics analysis to identify the biosynthetic gene clusters that are making those bioactive molecules using a metabologenomics platform.
Bioactivity-guided metabologenomics workflow for prioritizing bioactive natural product-BGC pairs for targeted downstream analyses
(Ref.: Ayon et al. Metabolomics 2024)
I grew 276 fungi strains under various growth conditions, extracted their secondary metabolites, and ran LC-MS/MS for metabologenomics and bioactivity screening.
I grew 276 fungi strains under various growth conditions, extracted their secondary metabolites, and ran LC-MS/MS for metabologenomics and bioactivity screening.
Bacterial Metabolomics
Bacterial Metabolomics
We used targeted LC-MS/MS methods to study the effect of drugs on cell wall and DNA biosynthesis pathway in bacteria.
Cytoplasmic intermediates and the enzymes involved in S. aureus cell wall biosynthesis pathway showing stepwise formation of functional units leading to peptidoglycan formation.
(Ref.: Vemula et al. Biochimie 2016)
Cytoplasmic intermediates and the enzymes involved in S. aureus DNA biosynthesis pathway showing stepwise formation of functional units leading to DNA formation.
(Ref.: Ayon ProQuest 2020)
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