Publications
Journals
Research Articles
Small Molecule Mass Spectrometry
Untargeted Metabolomics
Metabologenomics and Natural Products Drug Discovery
Metabologenomics identified new bioactive natural product analogs and their biosynthetic gene cluster. (Under Review)
Targeted Metabolomics
Amino Acids and Peptides
Enzyme Activity Analysis
DNA Nucleosides
High-Throughput Screening and Antibacterial Drug Discovery
Drug and Drug Metabolites
Drug Formulation Characterization
Microparticle and Nanomicellar Formulations
Solid Dispersion and Salt Formulation
Microspheres
Protein Mass Spectrometry
Top-Down Proteomics
Native I2MS
Characterizing amyloid beta oligomers of differing origin by Individual Ion Mass Spectrometry. (On Hold).
Conferences and Seminars
Posters
Jooß, K., Ives, A., Papin, A., Soshnev, A. A., Ayon, N. J. et al. (2023) Characterization of linker histone H1 proteoforms in naïve vs. germinal center B cells using CZE-MS. International Symposium on Microscale Separation and Bioanalysis.
Knox, B., Butun, F. A., Robey, M. T., Ayon, N. J. et al. (2023) Expanding functional access to fungal natural products with metabologenomics and heterologous expression. International Conference on Natural Product Discovery and Development in the Genomic Era.
Ayon, N. J., Caesar, L. K., Butun, F. A., et al. (2022) Identification of bioactive fungal secondary metabolites and their biosynthetic gene clusters using metabologenomics. American Society of Mass Spectrometry Conference.
Caesar, L. K., Butun, F. A., Ayon, N. J., et al. (2021) First Demonstration of combined Metabolomics and Genomics to Discover Bioactive Natural Products and their Biosynthetic Machinery in Fungi. American Society of Mass Spectrometry Conference.
Caesar, L. K., Butun, F. A., Ayon, N. J. et al. (2021) Integration of Metabolomic and Genomic Approaches to Explore Uncharted Biochemical Space in Fungi. American Council for Medicinally Active Plants Conference.
Ayon, N. J. et al. (2020) Multidimensional Chemical Library Screening for Novel Antibacterial Activities. American Association of Pharmaceutical Scientists Annual Conference.
Gargvanshi, S., Ayon, N. J. et al. (2020) Screening of FDA-Approved Drug Library against Vancomycin-resistant Enterococci. American Association of Pharmaceutical Scientists Annual Conference.
Sharma, A. D., Ayon, N. J. et al. (2019) Cell wall metabolite levels in S. aureus as a function of growth phase. American Association of Pharmaceutical Scientists Annual Conference.
Ayon, N. J. et al. (2019) Metabolism enhanced multiplexed FDA-approved drug screening for novel antibacterial activities. American Chemical Society National Meeting and Exposition.
Ayon, N. J., and Sobansky, M. R. (2019) Development and Optimization of Untargeted, Label Free, Bottom-Up Proteomics Workflow Using Ion Mobility Enabled Q-TOF LC-MS/MS for Plasma Protein Analysis. Streck Annual Intern Showcase.
Ayon, N. J. et al. (2019) LC-MS/MS based separation and quantification of Marfey’s derivatized Proteinogenic Amino Acid DL-stereoisomers. American Society of Mass Spectrometry Conference.
Ayon, N. J. et al. (2019) Serendipitous discovery of synergistic and antagonistic activity of FDA approved drugs against MRSA. UMKC Community of Scholar Symposium/Health Sciences Research Summit.
Ayon, N. J. et al. (2018) Discovery of antibacterial properties of pyrimidine derivatives by high throughput screening of pre-metabolized chemical library. American Association of Pharmaceutical Scientists Conference.
Ayon, N. J. et al. (2018) LC-MS/MS-based analytical method for Marfey's reagent derivatized amino acid stereoisomers. American Chemical Society National Meeting and Exposition.
Ayon, N. J. et al. (2018) Using biological chemistry for novel antibacterial agent discovery by high throughput screening of pre-metabolized chemical library. UMKC Community of Scholar Symposium.
Ayon, N. J. et al. (2017) Enhanced chemical diversity through library in situ pre-metabolism: Using biological chemistry for novel lead discovery. American Chemical Society National Meeting and Exposition.
Ayon, N. J. et al. (2016) Analytical method development for the determination of D-and L-amino acids by high performance liquid chromatography tandem mass spectrometry. Pharmaceutics Graduate Student Regional Meeting.
Vemula, H., Ayon, N. J. et al. (2016) Profiling of bacterial cell wall peptidoglycan pathway inhibitors using LC-MS/MS-based quantification of cytoplasmic pathway intermediates. American Chemical Society National Meeting and Exposition.
Presentations
McGee, J. P., Ayon, N. J., Kandi, S. et al. (2022) Probing Amyloid Beta Oligomers from Alzheimer’s Disease with Ion Mobility and Tandem Individual Ion Mass Spectrometry. American Society of Mass Spectrometry Conference.
Ayon, N. J. (2020) Dimensionally enhanced antibacterial library screening and application of mass spectrometry in DPPS research and beyond. Spring 2020 Seminar Series, UMKC School of Pharmacy, Kansas City, MO, USA.
Ayon, N.J. (2019) Development and optimization of proteomics workflow for plasma protein analysis. Streck’s Annual Intern Showcase Event, La Vista, NE, USA.
Ayon, N. J. (2019) Antibacterial drug repurposing using multiplexed compound library screening. Community of Scholars, Kansas City, MO, USA.
Ayon, N. J. (2018) Enhanced chemical diversity through library in-situ pre-metabolism: using biological chemistry for novel lead discovery. Spring 2018 Seminar Series, UMKC School of Pharmacy, Kansas City, MO, USA.
Ayon, N. J. (2016) Analytical method development for the determination of d- and l-amino acids by high performance liquid chromatography tandem mass spectrometry. Fall 2016 Seminar Series, UMKC School of Pharmacy, Kansas City, MO, USA.
Three Minute Thesis
Ayon, N. J. (2019) Separation of amino acid mirror images. Community of Scholars, Kansas City, MO, USA.
Ayon, N. J. (2018) Does biochemical transformation increase antibacterial hits? Community of Scholars, UMKC, Kansas City, MO, USA.
PhD Dissertation